For anyone in a family situation, from very difficult to near impossible. I can relate in the past to studying from home with a young family and sometimes also needing to fit it in around shift work. (8 years in total for TAFE and Post Grad remote learning)
Having a space to sit and work that is physically and socially separated is important. A study/home work space adjoining or close to any of the living areas, entries, cooking aromas etc is far from ideal. I ultimately converted a rear room, added an air con and used an outside door for access.
This is all predicated on your partner (M or F) being a full time non working supervisor if you have young children. It is also difficult for children to understand. We have extended family with both parents working who cannot work for home, and in lockdowns were required at work. They became heavily reliant on their now retired parents for filling the gaps. Possible assuming they live nearby, are free and inclined to help. The same need for friends or family to assist might relate to those with an essential worker in the family and the other working from home. Also needing to manage younger school or preschool aged children.
When we were reduced to a one parent family, and the working one holding the fort, we often relied on close friends living nearby. Something not always possible with Covid lockdowns and not an exception because you are working from home.
There are strategies for separation of time and space. They might only be possible if the other partner is committed to primary care where the children are younger, or the family is committed to full time paid day care or outside school care. Covid lockdowns excepted.